It is known that mental disorders such as anxiety and depression are extremely present in several clinical profiles.

Anxiety disorders are the most common group of mental illnesses. Brazil leads the world in the prevalence of anxiety (WHO, 2017). There are several factors that contribute to anxiety, including hormonal changes, genetics, and stress.

Over the past few years, much of the research on creatine (Cr) has been directed to its role as an important source of energy for muscle contraction during high-intensity physical or sports activities, and it is known that the increase in its plasma concentration promotes greater formation of the phosphocreatine complex (CrP) in muscle tissue and thus increases the energy available during exercise, prolonging the intensive work capacity of skeletal muscle, delaying muscle fatigue and promoting improved performance.

It is known that cerebrovascular health, during senescence, undergoes significant changes in its functionality. And among the observed implications, cognitive aging stands out.